The Detailed Information of Protein

Protein ID:	ICDB_Pro_1576
Protein Name:	Inositol 1;4;5-trisphosphate receptor-like protein A
Function:	May be a receptor for inositol 1;4;5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death.
Sequence:	MEEKNVNLKTGDLVTFFSEQEEEDGYFSKSHDSAVMSNNKSKDCVFKVYPFTQYTARKALKKKAKRKLQQQQADGADANNTNSSSGGGNSNNNNNNNSNSSNNNNSSNNNNNNNNNGTTNANGENVNNEVTDLELKQLEEYQDLEDVSNESTLIQLEGRDLVYGQIVQLYQPSSNQFLFARNNIVGFRQDGSQKCYFKITPRFQNQDGCKVFSEDLVLLRHEKTGLFLNQQNFIIDQGVFGIGLSENGTFWKMAVSDVDGKSGLNILKANEPFRLFHREGGFVKVSNDKTTFTYNTKTPSSINSLFEIEFENNNLISPLLRSQKDLQLQQKDNTDQLQQQQQKDKDKDNPLKQSYGSLSNSNILLQNNNNNNNNNNSNNNNNSNNNSNNSNGNNSNGNNNNNNSNNIFTSNEVHIGQSFWIRLVGTKKYLSLKESSDDSLKDNPLIVVTEDQKYSPSATFSFVKRDKANEDVIFGSFVRIQSLSKQYLHFISDETFHHNGELVGSKKYYKNDDFQIKQIPKSQLEDYGFVLSRINKIQNYLYQSSSNSSSSLMSSINGIGQSSFSSLAGATTTTTNSGGSNNINNNNNNNNNNNNNNNNNNNNNNNNNIDKKRATVQEIKAIIVEFIKFCTQSEVEDPLDREGTPIKTHQKLLSHPSHLSVLLDYLKRLFEPFDPASILFVYRLLKQMAKSNIKNGIIINEHLDQISPPSIRDKTIPLHFGAILYEVYKNNNILLEALTEDKVQEFINVIKQKKEPKYMELLSEICICYGKPIVKNQQYLCDLLLEKNSNLLFKTRVIGGSLEIERQNPAPKWVDITAFALSVDEKTHRYFEQSLALYSNVSKGRNYNGIRLVGQRITHKECLLALKEESLPYSLRGCYINILIHVYMDCHPQHYVPQINYVWNPSIVNNTKTIELLQLYQQYNITGSLHQRNSSIQNPYSTVSNGNISISSNNPISTTNTTTGSGGGGGGSGFMPTVGPSYGQASSPLSNGAIVNSLASTNLNNQTPTSLNLFNLNSPNNTTTTTNNSTNNTTNNNTNNNNNNNNTNSLITSTTHLIQLVSPQQNNNSNNNNNNNILNSIPTSPIVGSTNHGQLSHSGSNQTPLYQQQQQQQQQQQQQNSLSLFREDDIFSTFVNLEIQADKEPSTTTQLLISLLSKSEYFSNFNNGFPTSHRPQLAFFHKILIAVGYAFKFGFFRKKERVLLKRLRYILEFEHEPVNTFKEVDLGRTMGGSRMLEDESVIYVSIKIEIVNILHLMLSFQKKNIMDVFLYDFSNMSQSAFSQPENVKNQLIDRLTTNYQRDGHQDLSLCTVLFKLLKHENNQLSSLSLSLLNRIYKYRSIYAMLWSPIQKLFLLPNELTPTYKESLQKMESLTVTCFAPLTDDSTQESLRSLAFFIHLVTDSDPIKLVKNQKLLHVIGVHKTIIGVLKIGCSLDDLILDQSQPQHSQQQQQQHQQQPINISGSIDESSSTIPPLTTTTTTTTTTTTTTTTTQQSINFKSLLNSKTNSQSIHVAKIFRSCYEFLKVFCRDNRENQKVLFGEIEFLIGHLIRYGNVFGTVETLIEVFKNNIELAINFGNSPYLKLLVKFIINLSIDQLDPMFLRLLSVLILPCNENSVIENQISVTNLFKEYKSKISKLLVPISTMKEVMKDPKLLSKHYNVNSSNVYKLHLALQEILNHSLNDDGAGIGIGTTVIGGSIIGGSITTTAQTNINTITNTPTNNNSNNSNNNNTTNNNGTISHRHSNSTNTTQSVYPRLIRSSAKAQIVNSSVEILPKEFVINLELILLLKACSHGINTPTEVICREFLSMGECFDILIVRSDGNGKENSSLMINETKEYLENNLLFRFKSAYLSFLHEVFFNSDTLKGDLLALQLNHDLWSLIDQFTNQLNHLVTICAMNQMGQLYYVQMARNIIIPMVSVLERFYSQCFYFDKATQIHLTYSGRLMASLMKLYWKDPSLTIPFNQQNTSRYQSSLNMSPTNYDDSDTSEGGYHPILQGLDPEERVNIYSNLVKCLKAMDRSALSPIVPASVSTINISNVIKGCEDVINRTEHPNSRNRTETIDSSNSSPPLILSKSSSIYIDFTRLNNFVKLSKIRGYTEIAMMVNQSLSITPFIISHPNYNSNNSNNGNNNNNNNNGGGGNGNGGTIRSNSYISGGGGGSTTKRRTSRNNSNISDISNSGKGGSTISNRFQNSFSNTFIQQQQIGITNQRHINSGNTNIVTTVTSKSTNFLEILVFQLRNSLYDNDEMKINCIRILSSLLYINKERKPDIQNIMTDLYCHSAVIGLLSSKNIEIQFESLSLLLALLDDSVNVDNPLPNPKVKDDIQSHFSSSPDIQFFRDIYAMIERAKINLRDTKRNIHRIEHVKMGNNTVLGGNLTSKNSIKSSINNGNNSNNNNNRNGRVIDGCETNPYSTEFQLLQNIFRVLQLLCQGTTNIFKKSIRSQPDNYKSYDILKEMCQFLKILETIVNIDSDSIELGLRFFACMKEIVKNTPENQIAVTNVQVCKAVCNILKKTKENDPSKELKELKYLDLKIEVVDFLLHVIDKEDPRVMSKLIPELDYKVIESNTQVISQRSNHETNEKSIKLASMTFRLIKILADNDKSHNIQLEDCLLKCGEHCKSRIGRVELLYQNKLERIYFPIPNYSRRLILEDKEQSKIKNDENLLQENLEEHFINNKISWNKATEKIDAFMDYSEYKLIELEHLHNLKLNSMSYYLVSHTDKFKFLSFFLALIINLLLIIYSINSPPDLKQFKSDISDDYGIASWWAGFLPLTILQTICCILACVGFFLRKGPVLLYQNWVNYLKTHGHKKNFMFYTNDQRMHSLRQTFKYKFIPLNAKFLMTDLKAVYNILAVICSVLGIIYSPYFFAFHIFQFSLNTKALSLVLKAITMNKKTLLVMGVFILQAIYLLSIFSFVWFQEHYKDDDSEYMCGSLLQCFITNLYYGVPSQGQLIQFIKYNFPNNYLNTTDSTGSPTLEPIKTSNTVSARIIGWTVFNVAFYVVISLILLNVILGIIVDTFGQLRDQRAETEDYKSNVCFICSIERETFQKNSIEFKKHIEDDHNKWHYLYFFAYLKERCTNNQMNQLSELECSIADGITNRSYISFFPIEMSMSLQGIENANRKKEESIDQHAKLLDDVEKKITHNISTQFNQSISLLIDEIKNLRQQVSDLKQQQK
Gene Name:	iplA; DDB_G0292564
Organism:	Dictyostelium discoideum (Social amoeba)
Length:	3177
PDB:
Ligand Binding:	1. DICL_CP 2. DICL_Pep
AlphaFoldDB:	AF--F1-model_v4.pdb
Binding site:	289..293; 608..611; 692..694
Disease:
Location:
DOI ID:	10.1093/emboj/19.17.4846; 10.1038/nature03481; 10.1002/cm.10068; 10.1186/1471-2121-6-13; 10.1242/jcs.03248; 10.4161/auto.5521; 10.1016/j.ceca.2007.08.002; 10.1016/j.ceca.2008.04.001; 10.1091/mbc.e07-08-0823; 10.1016/j.bbamcr.2008.12.005
RefSeq:	XP_629509.1